Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746 | 0.89 | ALOX15 (0.68) | ALOX15SMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL8225239 | 0.81 | SMN1; SMN2 (0.67) | ALOX15SMN1; SMN2RAB9AALDH1A1HTT | |
| Anisole SCHEMBL28851690 | 0.81 | ALOX15 (0.59) | ALOX15SMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL9535986 | 0.79 | ALOX15 (0.55) | ALOX15SMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL2955123 | 0.78 | HPGD (0.50) | ALOX15SMN1; SMN2RAB9AMAPTALDH1A1 | |
| SCHEMBL7733929 | 0.78 | MAPT (0.66) | ALOX15SMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL12345884 | 0.75 | ALOX15 (0.50) | ALOX15SMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL20425306 | 0.75 | MAOB (0.70) | SMN1; SMN2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL11528650 | 0.75 | LMNA (0.59) | ALOX15L3MBTL1LMNA | |
| SCHEMBL2446915 | 0.75 | ELANE (0.62) | SMN1; SMN2KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241043-B1 | NOVEL DIARYLALKANOIDS HAVING ACTIVITY AS LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5177259-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| US-5142095-A | Treating inflammation, allergies, asthma, cardiovascular disorders, psoriasis | WARNER-LAMBERT COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-5077411-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, migraines, psoriasis | WARNER-LAMBERT CO. (US) | 1991-12-31 | — | — | US | disclosed |
| US-4959503-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1990-09-25 | — | — | US | disclosed |
| US-4810716-A | ANTIINFLAMMATORY, ANTIALLERGY, ANTIISCHEMIC | WARNER-LAMBERT COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0241043-A2 | Novel diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1987-10-14 | — | — | EP | disclosed |