Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ILK | Q13418 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11769657 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MAPTHTTKDM4EPOLB | |
| SCHEMBL11767665 | 0.83 | PKM (0.41) | ALDH1A1MAPTKDM4EPOLBCYP1A2 | |
| SCHEMBL11772038 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MAPTHTTKDM4EPOLB | |
| SCHEMBL11770069 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTCYP1A2HSP90AA1HSP90AB1 | |
| SCHEMBL11769764 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTCYP1A2HSP90AA1HSP90AB1 | |
| SCHEMBL9535982 | 0.77 | ALDH1A1 (0.51) | ALDH1A1MAPTHTTKDM4EPOLB | |
| SCHEMBL9535985 | 0.77 | ALDH1A1 (0.51) | ALDH1A1MAPTHTTKDM4EPOLB | |
| SCHEMBL22230643 | 0.76 | TARBP2 (0.53) | ALDH1A1MAPTHTTKDM4EPOLB | |
| SCHEMBL11768508 | 0.76 | ALDH1A1 (0.44) | ALDH1A1MAPTCYP1A2CYP2C9HSP90AA1 | |
| SCHEMBL8536518 | 0.76 | ALDH1A1 (0.51) | ALDH1A1MAPTCYP1A2CYP2C9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254595-A | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1993-10-19 | — | — | US | disclosed |
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |
| US-3940407-A | β-Adrenergic blocking agents in the 1,2,3-thiadiazole series | SYNTEX (U.S.A.) INC. (US) | 1976-02-24 | — | — | US | disclosed |