Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ILK | Q13418 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 2/20 | 0.39 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535985 | 0.89 | ALDH1A1 (0.51) | ALDH1A1CYP1A2CYP2C9HSD17B10MAPT | |
| SCHEMBL22230643 | 0.87 | TARBP2 (0.53) | ALDH1A1CYP1A2CYP2C9HSD17B10MAPT | |
| SCHEMBL6815148 | 0.87 | ILK (0.61) | ALDH1A1CYP1A2CYP2C9HSD17B10MAPT | |
| SCHEMBL11773257 | 0.79 | ILK (0.49) | ALDH1A1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL7586906 | 0.78 | ILK (0.55) | ALDH1A1CYP1A2CYP2C9HSD17B10MAPT | |
| SCHEMBL9536015 | 0.77 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2C9HSD17B10MAPT | |
| SCHEMBL11771172 | 0.75 | ILK (0.54) | ALDH1A1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL11770705 | 0.74 | ADRB2 (0.48) | CYP1A2MAPTMEN1KMT2ATSHR | |
| SCHEMBL11773521 | 0.73 | ADRB2 (0.49) | MAPTMEN1KMT2AHTT | |
| SCHEMBL7794327 | 0.73 | TSHR (0.61) | ALDH1A1CYP1A2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |