Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 5/20 | 0.56 |
| ▸ | ATIC | P31939 | 3/20 | 0.51 |
| ▸ | DHFR | P00374 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536050 | 0.95 | GART (0.50) | GARTATICDHFR | |
| SCHEMBL10479151 | 0.93 | GART (0.57) | GARTATIC | |
| SCHEMBL9536834 | 0.93 | GART (0.57) | GARTATICDHFR | |
| SCHEMBL10479169 | 0.93 | GART (0.57) | GARTATIC | |
| SCHEMBL10479205 | 0.93 | GART (0.57) | GARTATIC | |
| SCHEMBL10479203 | 0.93 | GART (0.57) | GARTATIC | |
| SCHEMBL10479154 | 0.93 | GART (0.57) | GARTATIC | |
| SCHEMBL9534949 | 0.91 | GART (0.58) | GARTATICDHFR | |
| SCHEMBL9446048 | 0.88 | GART (0.61) | GARTATICDHFR | |
| SCHEMBL9536853 | 0.88 | GART (0.51) | GARTATICDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215063-B1 | PYRIDO (2,3-d )PYRIMIDIN DERIVATIVES | UNIV PRINCETON (US) | 1993-11-03 | — | — | EP | claimed |
| EP-0215063-A4 | PYRIDO (2,3-d )PYRIMIDIN DERIVATIVES. | UNIV PRINCETON (US) | 1987-11-23 | — | — | EP | claimed |
| US-4684653-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1987-08-04 | — | — | US | claimed |
| EP-0215063-A1 | PYRIDO (2,3-d )PYRIMIDIN DERIVATIVES. | UNIV PRINCETON (US) | 1987-03-25 | — | — | EP | claimed |
| WO-1986005181-A1 | PYRIDO AD2,3-d BDPYRIMIDIN DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1986-09-12 | — | — | WO | claimed |
| EP-0215063-B1 | PYRIDO (2,3-d )PYRIMIDIN DERIVATIVES | UNIV PRINCETON (US) | 1993-11-03 | — | — | EP | disclosed |
| US-5026851-A | Antineoplastic agents | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-25 | — | — | US | disclosed |
| US-4845216-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-07-04 | — | — | US | disclosed |
| US-4684653-A | ANTITUMOR AGENTS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1987-08-04 | — | — | US | disclosed |