Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556056 | 0.80 | ALDH1A1 (0.82) | ALDH1A1KDM4ESMN1; SMN2RAB9AGAA | |
| SCHEMBL11667266 | 0.79 | ALOX15 (0.54) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL937188 | 0.78 | KMT2A (0.49) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL936476 | 0.78 | KMT2A (0.49) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL936475 | 0.78 | KMT2A (0.49) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL1195477 | 0.76 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL1195476 | 0.76 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL11655716 | 0.76 | RAB9A (0.52) | ALDH1A1KDM4ESMN1; SMN2RAB9AALOX15 | |
| SCHEMBL2561089 | 0.75 | ALDH1A1 (0.67) | ALDH1A1KMT2AKDM4EMEN1RAB9A | |
| SCHEMBL11650625 | 0.75 | ABCB1 (0.56) | KMT2AKDM4EMEN1SMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555251-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007838-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | disclosed |