Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831544 | 0.71 | HTR7 (0.39) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL1958637 | 0.71 | ALDH1A1 (0.39) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL525897 | 0.71 | ALDH1A1 (0.42) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL10502933 | 0.71 | ALDH1A1 (0.42) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL31171603 | 0.71 | HTR7 (0.39) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL6116674 | 0.70 | ALDH1A1 (0.38) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL476655 | 0.70 | ALDH1A1 (0.38) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL3542339 | 0.70 | ALDH1A1 (0.41) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL398169 | 0.70 | MAPT (0.54) | ALDH1A1PKMHPGDHTTL3MBTL1 | |
| SCHEMBL476656 | 0.70 | ACHE (0.41) | ALDH1A1PKMHPGDHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292979-B1 | NEW ALKANESULFONANILIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |
| US-5034417-A | Antiinflammatory agents or analgesics | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0292979-A2 | New alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-11-30 | — | — | EP | disclosed |