Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HPD | P32754 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536988 | 0.98 | SMN1; SMN2 (0.37) | SMN1; SMN2HSD17B10ALDH1A1CYP2D6KMT2A | |
| SCHEMBL10400747 | 0.93 | KMT2A (0.33) | HSD17B10ALDH1A1CYP2D6KMT2APDE4B | |
| SCHEMBL10401012 | 0.91 | KMT2A (0.35) | SMN1; SMN2HSD17B10ALDH1A1CYP2D6KMT2A | |
| SCHEMBL10401077 | 0.86 | PDE4B (0.41) | SMN1; SMN2ALDH1A1KMT2APDE4BPDE4D | |
| SCHEMBL10400129 | 0.86 | MAPT (0.44) | HSD17B10ALDH1A1KMT2APDE4BPDE4D | |
| SCHEMBL10400076 | 0.85 | SMN1; SMN2 (0.33) | SMN1; SMN2HSD17B10ALDH1A1CYP2D6KMT2A | |
| SCHEMBL9538333 | 0.85 | TP53 (0.36) | SMN1; SMN2HSD17B10ALDH1A1CYP2D6ACHE | |
| SCHEMBL10401051 | 0.84 | PDE4B (0.35) | HSD17B10CYP2D6KMT2APDE4BPDE4D | |
| SCHEMBL9537774 | 0.84 | PDE4B (0.41) | PDE4BPDE4DACHEPOLBPDK1 | |
| SCHEMBL9536816 | 0.83 | SMN1; SMN2 (0.35) | SMN1; SMN2HSD17B10ALDH1A1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337944-B1 | UREAS | CIBA-GEIGY AG (CH) | 1993-07-28 | — | — | EP | disclosed |
| EP-0337944-A1 | Ureas | CIBA-GEIGY AG (CH) | 1989-10-18 | — | — | EP | disclosed |