Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770718 | 0.86 | KDM4E (0.45) | ELANEPARP1PIK3CDPTGS2NPC1 | |
| SCHEMBL9533212 | 0.86 | PARP1 (0.40) | ELANEPARP1PIK3CDPTGS2DHODH | |
| SCHEMBL10695218 | 0.83 | ELANE (0.40) | ELANEPARP1PIK3CDNPC1LMNA | |
| SCHEMBL9535344 | 0.83 | ELANE (0.43) | ELANEPTGS2MAPT | |
| SCHEMBL9536487 | 0.83 | PTGS2 (0.36) | ELANEPARP1PTGS2NPC1LMNA | |
| SCHEMBL9770716 | 0.78 | PARP1 (0.44) | ELANEPARP1PTGS2DHODHTP53 | |
| SCHEMBL9533044 | 0.75 | ELANE (0.40) | ELANEPARP1PIK3CDPTGS2DHODH | |
| SCHEMBL9535141 | 0.74 | CYP1A2 (0.50) | ELANEPARP1PIK3CDNPC1LMNA | |
| SCHEMBL9770658 | 0.72 | KDM4E (0.46) | PARP1PTGS2TP53MAPTSMN1; SMN2 | |
| SCHEMBL9770643 | 0.72 | ELANE (0.39) | ELANEPARP1PIK3CDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263523-B1 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| US-5030727-A | Reacting an anthronilide derivative with a thiazole derivative or a fluorozuinazolone with a neucleophile | BASF AKTIENGESELLSCHAFT (DE) | 1991-07-09 | — | — | US | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |