Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770718 | 0.86 | KDM4E (0.45) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL9533212 | 0.86 | PARP1 (0.40) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL9770643 | 0.83 | ELANE (0.39) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL9770658 | 0.83 | KDM4E (0.46) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL10696348 | 0.83 | PDE10A (0.43) | PARP1MAPTPOLBRXFP1ELANE | |
| SCHEMBL10694401 | 0.81 | ELANE (0.47) | KDM4EALDH1A1HPGDMAPTPKM | |
| SCHEMBL9536653 | 0.78 | ELANE (0.40) | PARP1MAPTTP53ELANESMN1; SMN2 | |
| SCHEMBL10693610 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1HPGDMAPTPKM | |
| SCHEMBL9535817 | 0.75 | PARP1 (0.44) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL10696099 | 0.75 | PARP1 (0.44) | PARP1KDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5030727-A | Reacting an anthronilide derivative with a thiazole derivative or a fluorozuinazolone with a neucleophile | BASF AKTIENGESELLSCHAFT (DE) | 1991-07-09 | — | — | US | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |