Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531841 | 0.93 | PPARG (0.52) | MAPK8PPARGPLA2G2A | |
| SCHEMBL9535760 | 0.85 | AGTR1 (0.47) | MAPK8PPARGPLA2G2A | |
| SCHEMBL9690284 | 0.84 | MAPK8 (0.46) | MAPK8EGLN1PPARGPLA2G2AHDAC1 | |
| SCHEMBL9531469 | 0.84 | PPARG (0.49) | PPARG | |
| SCHEMBL9530978 | 0.82 | PPARG (0.51) | PPARG | |
| SCHEMBL9531904 | 0.82 | PPARG (0.50) | PPARGPLA2G2A | |
| SCHEMBL9690754 | 0.81 | MAPK8 (0.45) | MAPK8PPARGPLA2G2AHDAC1HDAC8 | |
| SCHEMBL9531601 | 0.80 | MAPK8 (0.43) | MAPK8EGLN1PLA2G2AHDAC1HDAC8 | |
| SCHEMBL9531316 | 0.79 | AGTR1 (0.54) | PPARG | |
| SCHEMBL9534507 | 0.77 | PPARG (0.53) | PPARGPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |