SCHEMBL9536693

SCHEMBL9536693

O=C(Cl)c1ccc(Oc2ccc(-c3ccccc3)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 2/20 0.53
MCL1 Q07820 2/20 0.53
BCL2L1 Q07817 1/20 0.53
SRD5A2 P31213 4/20 0.52
MAPT P10636 3/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ERCC5 P28715 1/20 0.46
FEN1 P39748 1/20 0.46
RAB9A P51151 2/20 0.46
ACACB O00763 1/20 0.46
ACACA Q13085 1/20 0.46
NPC1 O15118 1/20 0.46
CTDSP1 Q9GZU7 1/20 0.46
HPGD P15428 2/20 0.45
ALDH1A1 P00352 1/20 0.45
KMT2A Q03164 1/20 0.45
PARP15 Q460N3 1/20 0.45
PARP14 Q460N5 1/20 0.45
PARP16 Q8N5Y8 1/20 0.45
PARP11 Q9NR21 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9186446 0.96 PARP10 (0.58) PARP10MCL1BCL2L1SRD5A2SMN1; SMN2
SCHEMBL21786 0.90 PARP10 (0.64) PARP10SRD5A2MAPTSMN1; SMN2ERCC5
SCHEMBL9249310 0.90 PARP10 (0.64) PARP10SRD5A2MAPTSMN1; SMN2ERCC5
Diphenylether SCHEMBL9717017 0.88 PARP10 (0.61) PARP10SRD5A2SMN1; SMN2ERCC5FEN1
Biphenyl SCHEMBL28809192 0.88 SMN1; SMN2 (0.60) MAPTSMN1; SMN2ERCC5FEN1RAB9A
SCHEMBL8723556 0.88 SMN1; SMN2 (0.60) MAPTSMN1; SMN2ERCC5FEN1RAB9A
SCHEMBL14416 0.88 SMN1; SMN2 (0.60) MAPTSMN1; SMN2ERCC5FEN1RAB9A
SCHEMBL9452041 0.88 SMN1; SMN2 (0.60) MAPTSMN1; SMN2ERCC5FEN1RAB9A
Hydrochloric Acid SCHEMBL10411245 0.86 PARP10 (0.60) PARP10SRD5A2SMN1; SMN2ERCC5FEN1
Biphenyl SCHEMBL8775397 0.86 SMN1; SMN2 (0.58) MAPTSMN1; SMN2ERCC5FEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0178183-B1 PREPARATION OF AROMATIC KETONE-SULFONE COPOLYMERS RAYCHEM CORPORATION (a Delaware corporation) (US) 1993-01-20 EP disclosed
US-4593086-A From carboxylic acid halide and aromatic dicarboxylic acid dihalide RAYCHEM CORPORATION (US) 1986-06-03 US disclosed
EP-0178183-A2 Preparation of aromatic ketone-sulfone copolymers RAYCHEM CORPORATION (a Delaware corporation) (US) 1986-04-16 EP disclosed
EP-0069597-B1 PREPARING P-PHENOXY-BENZOYL COMPOUNDS RAYCHEM CORPORATION (a California corporation) (US) 1984-10-10 EP disclosed
US-4474990-A Preparing p-phenoxy benzoyl compounds RAYCHEM CORPORATION (US) 1984-10-02 US disclosed
EP-0069597-A1 Preparing p-phenoxy-benzoyl compounds RAYCHEM CORPORATION (a California corporation) (US) 1983-01-12 EP disclosed
US-4229564-A SUITABLE FOR MELT PROCESSING AND EXTRUSION COATINGS RAYCHEM CORPORATION (US) 1980-10-21 US disclosed
US-4111908-A POLYKETONES AND METHODS THEREFOR RAYCHEM CORPORATION (US) 1978-09-05 US disclosed
US-3965146-A POLYMER INTERMEDIATE RAYCHEM CORPORATION (US) 1976-06-22 US disclosed