Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10576624 | 0.85 | DRD2 (0.48) | DRD2HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL2395487 | 0.82 | DRD2 (0.59) | DRD2HTR1ALMNADRD4HTR2A | |
| SCHEMBL3436392 | 0.81 | DRD2 (0.43) | DRD2HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL11714871 | 0.80 | SIGMAR1 (0.60) | DRD2HTR1ADRD4SIGMAR1 | |
| SCHEMBL9533235 | 0.79 | HTR1D (0.44) | DRD2HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL3554023 | 0.78 | DRD2 (0.43) | DRD2HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL3436835 | 0.78 | DRD2 (0.43) | DRD2HTR1AKDM4ELMNAALOX15 | |
| Hydrochloric Acid SCHEMBL2263936 | 0.78 | KDM4E (0.55) | DRD2HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL1078756 | 0.78 | KDM4E (0.55) | DRD2HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL29387382 | 0.78 | KDM4E (0.55) | DRD2HTR1AKDM4ELMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254623-B1 | AMINOALKYLTHIO TRIAZOLOPYRIDINE OR TRIAZOLOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, PARTICULARLY USEFUL AS ANTALGICS | LABORATOIRES UPSA (FR) | 1993-06-09 | — | — | EP | disclosed |
| US-4886805-A | Novel aminoalkylthio derivatives of triazolopyridine or triazoloquinoline, the processes for their preparation, and drugs, useful especially as analgesics, in which they are present | Centre D'Activite Et De Recherches Pharmaceutique Industrielle Biologique Medicale (FR) | 1989-12-12 | — | — | US | disclosed |
| EP-0254623-A1 | Aminoalkylthio triazolopyridine or triazoloquinoline derivatives, process for their preparation, medicaments containing them, particularly useful as antalgics | LABORATOIRES UPSA (FR) | 1988-01-27 | — | — | EP | disclosed |