Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | FNTA | P49354 | 1/20 | 0.54 |
| ▸ | FNTB | P49356 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923846 | 0.88 | KDM4E (0.56) | LMNAKDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL1165573 | 0.85 | KDM4E (0.68) | LMNAKDM4EPKMMAPTHSD17B10 | |
| SCHEMBL31487317 | 0.85 | KDM4E (0.68) | LMNAKDM4EPKMMAPTHSD17B10 | |
| SCHEMBL14367892 | 0.85 | EGFR (0.68) | — | |
| SCHEMBL3107169 | 0.84 | KDM4E (0.61) | LMNAKDM4EPKMHSD17B10MEN1 | |
| SCHEMBL5198795 | 0.84 | KDM4E (0.64) | LMNAKDM4EPKMMAPTHSD17B10 | |
| SCHEMBL4438241 | 0.83 | KDM4E (0.62) | LMNAKDM4EPKMMAPTHSD17B10 | |
| SCHEMBL28156124 | 0.82 | HTR2A (0.52) | LMNAKDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL4266152 | 0.82 | HTR6 (0.70) | LMNAKDM4EPKMMAPTHSD17B10 | |
| SCHEMBL4259037 | 0.81 | KDM4E (0.57) | LMNAKDM4EPKMMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546164-A1 | INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | FIDIA RESEARCH FOUNDATION (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5206382-A | INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | FIDIA GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1993-04-27 | — | — | US | disclosed |
| WO-1993000334-A1 | INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | FIDIA - GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1993-01-07 | — | — | WO | disclosed |