SCHEMBL6923846

SCHEMBL6923846

CCOC(=O)Cc1c(-c2ccccc2)[nH]c2ccc(C)cc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.56
HPGD P15428 3/20 0.56
ALDH1A1 P00352 3/20 0.56
GFER P55789 1/20 0.56
LMNA P02545 2/20 0.55
MEN1 O00255 2/20 0.55
GAA P10253 2/20 0.55
MAPT P10636 2/20 0.55
KMT2A Q03164 2/20 0.55
HSD17B10 Q99714 2/20 0.55
CYP1A2 P05177 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
MAPK10 P53779 1/20 0.55
PPARG P37231 2/20 0.54
PIM1 P11309 1/20 0.52
TACR1 P25103 1/20 0.50
POLB P06746 1/20 0.49
USP2 O75604 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9536890 0.88 LMNA (0.62) KDM4EHPGDALDH1A1LMNAMEN1
SCHEMBL7238606 0.88 PPARG (0.55) KDM4EHPGDALDH1A1GFERLMNA
SCHEMBL6929315 0.85 KDM4E (0.69) KDM4EHPGDALDH1A1GFERMEN1
SCHEMBL8291738 0.83 KDM4E (0.69) KDM4EHPGDALDH1A1LMNAMEN1
SCHEMBL10936333 0.82 HPGD (0.56) KDM4EHPGDALDH1A1GFERMEN1
SCHEMBL11657694 0.81 HPGD (0.62) KDM4EHPGDALDH1A1GFERLMNA
SCHEMBL6925963 0.80 ALDH1A1 (0.61) KDM4EHPGDALDH1A1GFERLMNA
SCHEMBL28906379 0.80 HPGD (0.63) KDM4EHPGDALDH1A1GFERLMNA
SCHEMBL30745615 0.80 HPGD (0.63) KDM4EHPGDALDH1A1GFERLMNA
SCHEMBL27195463 0.80 ALDH1A1 (0.66) KDM4EHPGDALDH1A1LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6518273-B1 2-aryl indole derivative as antagonists of tachykinins MERCK SHARP & DOHME LTD. 2003-02-11 US disclosed
WO-2000051984-A1 2-ARYL INDOLE DERIVATIVES AS ANTAGONISTS OF TACHYKININS MERCK SHARP & DOHME LIMITED (GB) 2000-09-08 WO disclosed