Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383332 | 0.87 | KCNH2 (0.44) | KCNH2MAPTHPGDTSHRNPY1R | |
| SCHEMBL9537178 | 0.83 | MEN1 (0.50) | MAPTHTTCYP2D6 | |
| SCHEMBL9540254 | 0.82 | TSHR (0.52) | KCNH2TSHRNPY1RNOS2NOS3 | |
| SCHEMBL9690875 | 0.81 | TP53 (0.42) | KCNH2MAPTNPY1R | |
| SCHEMBL9537111 | 0.81 | KCNH2 (0.63) | KCNH2MAPTHTTHTR3ANR4A2 | |
| SCHEMBL9537283 | 0.80 | KCNH2 (0.58) | KCNH2MAPTNPY1RHTTHTR3A | |
| SCHEMBL9697200 | 0.80 | KCNH2 (0.62) | KCNH2MAPTTSHRNPC1RAB9A | |
| Water SCHEMBL10550887 | 0.79 | KCNH2 (0.57) | KCNH2MAPTNPY1RHTTHTR3A | |
| SCHEMBL14173582 | 0.79 | KCNH2 (0.50) | KCNH2NPY1RNOS2NOS3NOS1 | |
| SCHEMBL9534954 | 0.78 | SMN1; SMN2 (0.52) | KCNH2MAPTHPGDTSHRNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |