Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9382748 | 0.88 | MEN1 (0.50) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8565760 | 0.86 | MEN1 (0.48) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL5626341 | 0.86 | MEN1 (0.66) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL9593584 | 0.86 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9384112 | 0.85 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9535902 | 0.84 | MEN1 (0.63) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9539854 | 0.84 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9593592 | 0.84 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9536944 | 0.83 | KCNH2 (0.49) | CYP2D6MAPTHTT | |
| SCHEMBL8138405 | 0.81 | MEN1 (0.51) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |