Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 3/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.42 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10818505 | 0.91 | TSHR (0.44) | TSHRKDM4EUSP2ALDH1A1HSD17B10 | |
| Fumaric Acid SCHEMBL11015217 | 0.91 | TSHR (0.44) | TSHRKDM4EUSP2ALDH1A1HSD17B10 | |
| SCHEMBL9537090 | 0.84 | TP53 (0.44) | TSHRKDM4EUSP2ALDH1A1HSD17B10 | |
| SCHEMBL9539854 | 0.83 | ALDH1A1 (0.52) | TSHRKDM4EUSP2ALDH1A1HSD17B10 | |
| SCHEMBL9536944 | 0.82 | KCNH2 (0.49) | TSHRKCNH2NPY1RNOS2NOS3 | |
| SCHEMBL9383332 | 0.82 | KCNH2 (0.44) | TSHRKCNH2NPY1RNOS2NOS3 | |
| SCHEMBL9537283 | 0.82 | KCNH2 (0.58) | ALDH1A1KCNH2NPY1RHTTSMN1; SMN2 | |
| SCHEMBL9537470 | 0.82 | KDM4E (0.50) | TSHRKDM4EUSP2ALDH1A1HSD17B10 | |
| SCHEMBL9535315 | 0.82 | ALDH1A1 (0.47) | TSHRKDM4EUSP2ALDH1A1HSD17B10 | |
| Water SCHEMBL10550887 | 0.81 | KCNH2 (0.57) | ALDH1A1KCNH2NPY1RHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |