Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.47 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9472243 | 0.78 | PTGS2 (0.49) | PTGS2PTGS1ALOX5WDR5ALDH1A1 | |
| SCHEMBL10445152 | 0.73 | CYP2D6 (0.37) | PTGS2PTGS1ALOX5HSD11B1HRH3 | |
| SCHEMBL9458661 | 0.72 | CYP2D6 (0.39) | PTGS2PTGS1HSD11B1HRH3 | |
| SCHEMBL5555116 | 0.69 | GCGR (0.50) | GCGRHSD11B1 | |
| SCHEMBL6546895 | 0.68 | GCGR (0.47) | GCGRHSD11B1 | |
| Toluene SCHEMBL27833736 | 0.65 | GCGR (0.43) | GCGRHSD11B1 | |
| SCHEMBL1024527 | 0.64 | PDCD1 (0.47) | PTGS2ALOX5GCGRHSD11B1 | |
| SCHEMBL15536291 | 0.63 | PSMB5 (0.43) | GCGRHSD11B1 | |
| SCHEMBL4630089 | 0.63 | GCGR (0.44) | GCGRHSD11B1 | |
| SCHEMBL1921651 | 0.63 | PPARA (0.49) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397175-B1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | DANNHARDT GERD PROF DR (DE) | 1993-12-08 | — | — | EP | disclosed |
| EP-0397175-A1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | Dannhardt, Gerd, Prof.Dr. (DE) | 1990-11-14 | — | — | EP | disclosed |