Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535432 | 0.93 | TP53 (0.40) | SLC6A9TP53POLBMAPTLMNA | |
| SCHEMBL10549563 | 0.92 | SLC6A9 (0.50) | SLC6A9TP53POLBMAPTLMNA | |
| SCHEMBL9539506 | 0.89 | SSTR5 (0.44) | TP53MAPTLMNATSHR | |
| SCHEMBL10803216 | 0.88 | SLC6A9 (0.40) | SLC6A9TP53MAPTENPP2TSHR | |
| SCHEMBL9537795 | 0.88 | TSHR (0.41) | SLC6A9TP53MAPTENPP2TSHR | |
| SCHEMBL9536927 | 0.86 | SLC6A9 (0.56) | SLC6A9TP53POLBMAPTENPP2 | |
| SCHEMBL9536208 | 0.86 | SLC6A9 (0.41) | SLC6A9TP53POLBMAPTLMNA | |
| SCHEMBL9535415 | 0.84 | SLC6A9 (0.55) | SLC6A9TP53POLBMAPTLMNA | |
| SCHEMBL9536111 | 0.84 | SLC6A9 (0.44) | SLC6A9LMNATSHR | |
| SCHEMBL9536096 | 0.83 | MEN1 (0.46) | MAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |