Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537396 | 0.88 | SLC6A9 (0.48) | TSHRSLC6A9TP53ENPP2MAPT | |
| SCHEMBL9535432 | 0.88 | TP53 (0.40) | TSHRSLC6A9TP53ENPP2MAPT | |
| SCHEMBL9536927 | 0.87 | SLC6A9 (0.56) | TSHRSLC6A9GRIN2BTP53ENPP2 | |
| SCHEMBL9536208 | 0.87 | SLC6A9 (0.41) | TSHRSLC6A9KDM4EGRIN2BGRIN2A | |
| SCHEMBL10803216 | 0.87 | SLC6A9 (0.40) | TSHRSLC6A9GRIN2BGRIN2ATP53 | |
| SCHEMBL9536111 | 0.85 | SLC6A9 (0.44) | TSHRSLC6A9HRH1KDM4ESMN1; SMN2 | |
| SCHEMBL10549563 | 0.81 | SLC6A9 (0.50) | TSHRSLC6A9GRIN2BGRIN2ATP53 | |
| SCHEMBL9536096 | 0.81 | MEN1 (0.46) | TSHRHRH1GRIN2BGRIN2AKCNH2 | |
| Fumaric Acid SCHEMBL10383229 | 0.80 | SLC6A9 (0.41) | TSHRSLC6A9HRH1KDM4ESMN1; SMN2 | |
| SCHEMBL9535120 | 0.79 | TSHR (0.41) | TSHRHRH1SMN1; SMN2TP53KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |