Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535315 | 0.90 | ALDH1A1 (0.47) | KDM4ETSHRPOLBALDH1A1USP2 | |
| SCHEMBL9537714 | 0.87 | ALDH1A1 (0.45) | KDM4ETSHRALDH1A1USP2HSD17B10 | |
| SCHEMBL9539854 | 0.87 | ALDH1A1 (0.52) | KDM4EHRH1TSHRALDH1A1USP2 | |
| SCHEMBL9535911 | 0.85 | ALDH1A1 (0.43) | KDM4ETSHRALDH1A1USP2HSD17B10 | |
| SCHEMBL9535187 | 0.85 | ALDH1A1 (0.45) | KDM4ETSHRPOLBALDH1A1USP2 | |
| SCHEMBL9536425 | 0.85 | KDM4E (0.43) | KDM4EHRH1TSHRPOLBALDH1A1 | |
| Fumaric Acid SCHEMBL11069587 | 0.84 | ALDH1A1 (0.41) | KDM4EHRH1TSHRPOLBALDH1A1 | |
| SCHEMBL9536155 | 0.84 | USP2 (0.42) | KDM4EHRH1TSHRPOLBALDH1A1 | |
| SCHEMBL9537584 | 0.84 | MEN1 (0.56) | KDM4EHRH1TSHRPOLBALDH1A1 | |
| SCHEMBL9535185 | 0.84 | MAPT (0.49) | KDM4EPOLBALDH1A1USP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |