Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 6/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9537639 | 1.00 | MCHR1 (0.42) | MCHR1HRH1TACR2TACR1TP53 | |
| SCHEMBL9539265 | 0.98 | HRH1 (0.43) | MCHR1HRH1TACR2TACR1TP53 | |
| Oxalic Acid SCHEMBL10551011 | 0.90 | TP53 (0.44) | MCHR1HRH1TACR2TACR1TP53 | |
| Oxalic Acid SCHEMBL10798151 | 0.90 | TP53 (0.46) | MCHR1HRH1TACR2TACR1TP53 | |
| Oxalic Acid SCHEMBL10798146 | 0.90 | TP53 (0.46) | MCHR1HRH1TACR2TACR1TP53 | |
| SCHEMBL9540474 | 0.89 | SSTR5 (0.46) | MCHR1HRH1TACR2TACR1TP53 | |
| SCHEMBL10550679 | 0.85 | RAB9A (0.46) | MCHR1HRH1TACR2TACR1TP53 | |
| SCHEMBL10551189 | 0.82 | SSTR5 (0.47) | HRH1TACR2TACR1TP53CYP2D6 | |
| Oxalic Acid SCHEMBL10552513 | 0.82 | SSTR5 (0.51) | MCHR1HRH1TACR2TACR1TP53 | |
| Oxalic Acid SCHEMBL9538585 | 0.80 | SLC6A9 (0.43) | MCHR1HRH1TACR2TACR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |