Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | C1R | P00736 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319578 | 0.85 | L3MBTL1 (0.46) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL3537107 | 0.81 | CYP2C9 (0.50) | CA12CA9KDM4EL3MBTL1CA1 | |
| SCHEMBL2154703 | 0.77 | KMT2A (0.49) | ALDH1A1KDM4EMAPTL3MBTL1CYP2C9 | |
| SCHEMBL7840513 | 0.75 | ALDH1A1 (0.52) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL10714640 | 0.74 | MEN1 (0.46) | CA12CA9ALDH1A1KDM4ELMNA | |
| SCHEMBL9317773 | 0.74 | PSEN1 (0.64) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL454618 | 0.71 | CA12 (0.78) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL10873331 | 0.70 | ESR2 (0.44) | ALDH1A1KDM4EMAPTLMNACYP2C9 | |
| SCHEMBL70004 | 0.69 | KDM4E (0.68) | CA12CA9ALDH1A1KDM4ELMNA | |
| SCHEMBL29599456 | 0.69 | KDM4E (0.68) | CA12CA9ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553263-A1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992006975-A1 | 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |