Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.44 |
| ▸ | PLD2 | O14939 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9538011 | 1.00 | PLD2 (0.47) | PLD2CCR3POLBMAPTSSTR5 | |
| SCHEMBL9536186 | 0.90 | MAPT (0.56) | CCR3POLBMAPTSSTR5SLC6A2 | |
| Oxalic Acid SCHEMBL9539654 | 0.89 | SSTR5 (0.44) | POLBSSTR5TP53NR4A2KCNH2 | |
| Oxalic Acid SCHEMBL10554393 | 0.87 | SLC6A2 (0.51) | CCR3POLBSSTR5SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL10554399 | 0.87 | SLC6A2 (0.51) | CCR3POLBSSTR5SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL9540591 | 0.87 | ALDH1A1 (0.53) | CCR3POLBSSTR5SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL9540585 | 0.87 | ALDH1A1 (0.53) | CCR3POLBSSTR5SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL9537867 | 0.86 | POLB (0.46) | CCR3POLBSSTR5SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL9537860 | 0.86 | POLB (0.46) | CCR3POLBSSTR5SLC6A2SLC6A4 | |
| SCHEMBL9539081 | 0.85 | SLC6A2 (0.51) | CCR3POLBSSTR5SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |