Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9537163 | 0.99 | KDM4E (0.42) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9307067 | 0.84 | ALDH1A1 (0.44) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9699749 | 0.83 | KDM4E (0.51) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9537839 | 0.81 | HSD17B10 (0.52) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9537175 | 0.81 | HRH1 (0.53) | KDM4EALDH1A1TSHR | |
| SCHEMBL9629616 | 0.80 | KDM4E (0.49) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8561156 | 0.80 | ALDH1A1 (0.42) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9629717 | 0.80 | KDM4E (0.46) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9537827 | 0.80 | TSHR (0.46) | KDM4EHSD17B10SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9536342 | 0.79 | ALDH1A1 (0.50) | ALDH1A1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |