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SCHEMBL9538283

SCHEMBL9538283

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(C(F)(F)F)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.47
▸ THRB P10828 1/20 0.38
▸ CA2 P00918 2/20 0.35
▸ CA1 P00915 1/20 0.32
▸ MMP1 P03956 1/20 0.32
▸ MMP2 P08253 1/20 0.32
▸ MMP9 P14780 1/20 0.32
▸ MMP8 P22894 1/20 0.32
▸ MMP13 P45452 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38665316 1.00 LMNA (0.47) LMNATHRBCA2CA1MMP1
SCHEMBL9536133 0.96 LMNA (0.41) LMNATHRBCA2
SCHEMBL8744157 0.87 LMNA (0.41) LMNATHRBCA2
SCHEMBL9539402 0.83 LMNA (0.39) LMNATHRB
SCHEMBL1271660 0.82 LMNA (0.35) LMNA
SCHEMBL984715 0.82 LMNA (0.61) LMNATHRBCA2CA1MMP1
Perflexane SCHEMBL7507426 0.82 LMNA (0.61) LMNATHRBCA2CA1MMP1
SCHEMBL1924377 0.82 LMNA (0.61) LMNATHRBCA2CA1MMP1
Perflexane SCHEMBL3671912 0.82 LMNA (0.61) LMNATHRBCA2CA1MMP1
Perflexane SCHEMBL20769778 0.82 LMNA (0.61) LMNATHRBCA2CA1MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993005200-A1 AZEOTROPE-LIKE COMPOSITIONS OF 1,1-DICHLORO-1-FLUOROETHANE AND PERFLUOROCARBONS AND OPTIONALLY NITROMETHANE ALLIED-SIGNAL INC. (US) 1993-03-18 — — WO disclosed