Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536349 | 1.00 | ALDH1A1 (0.60) | ALDH1A1HTTL3MBTL1CNR2KDM4E | |
| SCHEMBL10762568 | 0.86 | CCR2 (0.55) | KDM4EMAPK1NPSR1PSEN1PSEN2 | |
| SCHEMBL10758013 | 0.86 | CCR2 (0.55) | KDM4EMAPK1NPSR1PSEN1PSEN2 | |
| SCHEMBL8358463 | 0.85 | ALDH1A1 (0.76) | ALDH1A1HTTL3MBTL1CNR2KDM4E | |
| SCHEMBL9259706 | 0.85 | ALDH1A1 (0.76) | ALDH1A1HTTL3MBTL1CNR2KDM4E | |
| SCHEMBL9868002 | 0.81 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1KDM4ENPSR1 | |
| SCHEMBL9538311 | 0.81 | CCR2 (0.60) | ALDH1A1KDM4ELMNAMAPK1 | |
| SCHEMBL31383501 | 0.79 | KDM4E (0.60) | ALDH1A1HTTL3MBTL1CNR2KDM4E | |
| SCHEMBL11185256 | 0.78 | KDM4E (0.46) | ALDH1A1L3MBTL1KDM4ELMNAMAPK1 | |
| SCHEMBL5797851 | 0.77 | CNR2 (0.73) | ALDH1A1CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |