Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9710053 | 0.89 | AGTR1 (0.46) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL9154007 | 0.88 | AGTR1 (0.44) | AGTR1LTB4R2ABCB11GP6TSHR | |
| SCHEMBL9709506 | 0.87 | AGTR1 (0.46) | AGTR1LTB4R2 | |
| SCHEMBL9709619 | 0.84 | AGTR1 (0.44) | AGTR1TSHR | |
| SCHEMBL9467974 | 0.84 | AGTR1 (0.42) | AGTR1 | |
| SCHEMBL9152304 | 0.83 | AGTR1 (0.42) | AGTR1TSHRMAPK1L3MBTL1 | |
| SCHEMBL9566964 | 0.82 | AGTR1 (0.42) | AGTR1LTB4R2ABCB11GP6TSHR | |
| SCHEMBL9430243 | 0.81 | TSHR (0.44) | AGTR1LTB4R2TSHRMAPK1L3MBTL1 | |
| SCHEMBL9710078 | 0.80 | AGTR1 (0.43) | AGTR1TSHR | |
| SCHEMBL9467980 | 0.79 | AGTR1 (0.36) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993005025-A1 | C-LINKED PYRAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-03-18 | — | — | WO | disclosed |
| EP-0446062-A1 | C-Linked pyrazole derivatives | GLAXO GROUP LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |