Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9710053 | 0.97 | AGTR1 (0.46) | AGTR1TP53AGTR2LTB4R2 | |
| SCHEMBL9709619 | 0.94 | AGTR1 (0.44) | AGTR1TP53AGTR2MEN1KMT2A | |
| SCHEMBL9710078 | 0.91 | AGTR1 (0.43) | AGTR1TP53AGTR2MEN1KMT2A | |
| SCHEMBL9538443 | 0.87 | AGTR1 (0.46) | AGTR1LTB4R2 | |
| SCHEMBL9154007 | 0.85 | AGTR1 (0.44) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL9709708 | 0.84 | AGTR1 (0.41) | AGTR1TP53AGTR2MEN1KMT2A | |
| SCHEMBL9289618 | 0.82 | AGTR1 (0.46) | AGTR1TP53AGTR2LTB4R2 | |
| SCHEMBL9430243 | 0.81 | TSHR (0.44) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL9152304 | 0.81 | AGTR1 (0.42) | AGTR1TP53AGTR2MEN1KMT2A | |
| SCHEMBL9566964 | 0.81 | AGTR1 (0.42) | AGTR1AGTR2LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0507594-A1 | Substituted quinolines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-10-07 | — | — | EP | disclosed |