Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 8/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566964 | 0.91 | AGTR1 (0.42) | TSHRMAPK1L3MBTL1AGTR1AGTR2 | |
| SCHEMBL9137311 | 0.84 | AGTR1 (0.40) | TSHRAGTR1AGTR2LTB4R2 | |
| SCHEMBL9710053 | 0.83 | AGTR1 (0.46) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL9538443 | 0.81 | AGTR1 (0.46) | TSHRMAPK1L3MBTL1AGTR1LTB4R2 | |
| SCHEMBL9709506 | 0.81 | AGTR1 (0.46) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL9154007 | 0.79 | AGTR1 (0.44) | TSHRMAPK1L3MBTL1AGTR1AGTR2 | |
| SCHEMBL9709619 | 0.78 | AGTR1 (0.44) | TSHRAGTR1AGTR2 | |
| SCHEMBL8802076 | 0.77 | AGTR1 (0.45) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL9024939 | 0.76 | LTB4R2 (0.58) | AGTR1LTB4R2 | |
| SCHEMBL8671881 | 0.76 | LTB4R2 (0.57) | AGTR1AGTR2LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371233-A | 2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation and their use as synthetic intermediates | SYNTHELABO (FR) | 1994-12-06 | — | — | US | disclosed |