Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585668 | 0.88 | ALOX5 (0.49) | ALOX5ALDH1A1POLBMAPTPKM | |
| SCHEMBL9541471 | 0.88 | ALOX5 (0.49) | ALOX5ALDH1A1MAPTPKMHTT | |
| SCHEMBL9833394 | 0.82 | ALOX5 (0.74) | ALOX5ALDH1A1POLBMAPTPKM | |
| SCHEMBL8806200 | 0.79 | ALOX5 (1.00) | ALOX5ALDH1A1POLBMAPTPKM | |
| SCHEMBL9539738 | 0.79 | ALOX5 (0.61) | ALOX5ALDH1A1POLBMAPTPKM | |
| SCHEMBL9583744 | 0.78 | ALOX5 (0.46) | ALOX5 | |
| SCHEMBL9584912 | 0.75 | CYP2E1 (0.45) | ALOX5POLBCYP2E1CYP3A4CYP2A6 | |
| SCHEMBL9542504 | 0.74 | ALOX5 (0.60) | ALOX5ALDH1A1POLBMAPTTDP1 | |
| SCHEMBL9834288 | 0.73 | ALOX5 (0.59) | ALOX5ALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9832912 | 0.71 | ALOX5 (0.43) | ALOX5MAPTTDP1CYP2C19MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003719-A1 | ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY | ABBOTT LABORATORIES (US) | 1993-03-04 | — | — | WO | claimed |
| US-5183818-A | Also for inhibiting leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1993-02-02 | — | — | US | disclosed |