Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834151 | 0.83 | ALOX5 (0.47) | ALOX5 | |
| SCHEMBL9832067 | 0.83 | ALOX5 (0.45) | ALOX5 | |
| SCHEMBL9832912 | 0.80 | ALOX5 (0.43) | ALOX5TSHRMEN1CYP1A2CYP2C19 | |
| SCHEMBL9833394 | 0.75 | ALOX5 (0.74) | ALOX5TSHRCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8807135 | 0.74 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL9379875 | 0.74 | ALOX5 (0.53) | ALOX5DAOHTR2BALDH1A1 | |
| SCHEMBL9379872 | 0.74 | ALOX5 (0.53) | ALOX5DAOHTR2BALDH1A1 | |
| SCHEMBL9538830 | 0.73 | ALOX5 (0.65) | ALOX5CYP2D6CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9831016 | 0.73 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL9833184 | 0.72 | ALOX5 (0.51) | ALOX5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388429-A4 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0388429-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| WO-1989004299-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-05-18 | — | — | WO | disclosed |