Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539704 | 0.82 | ALOX5 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6028094 | 0.82 | GAA (0.45) | GAAALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9542499 | 0.79 | AGXT (0.52) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5039818 | 0.79 | ALOX5 (0.50) | GAAALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9542445 | 0.78 | SLC1A3 (0.50) | GAAALDH1A1POLBALOX5L3MBTL1 | |
| SCHEMBL26057925 | 0.75 | GPR35 (0.47) | GAAALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL9539825 | 0.74 | ALOX5 (0.39) | ALOX5MMP2 | |
| SCHEMBL9584912 | 0.71 | CYP2E1 (0.45) | HDAC3HDAC1HDAC2HDAC8POLB | |
| SCHEMBL9584641 | 0.70 | MMP2 (0.37) | ALOX5MMP2 | |
| SCHEMBL9542504 | 0.70 | ALOX5 (0.60) | GAAALDH1A1POLBALOX5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003719-A1 | ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY | ABBOTT LABORATORIES (US) | 1993-03-04 | — | — | WO | claimed |
| US-5183818-A | Also for inhibiting leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1993-02-02 | — | — | US | disclosed |