Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | MGMT | P16455 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540456 | 0.79 | ALOX5 (0.36) | HSD17B10LMNACDK1CCNB1MGMT | |
| SCHEMBL9540433 | 0.77 | LMNA (0.43) | L3MBTL1LMNACYP1A2CDK1CYP3A4 | |
| SCHEMBL10359891 | 0.69 | KMT2A (0.52) | KMT2AMEN1HTTGFERHSD17B10 | |
| SCHEMBL9542967 | 0.67 | CSNK2A2 (0.34) | KMT2AMEN1MGMTTSHR | |
| SCHEMBL37382 | 0.66 | ALDH1A1 (0.68) | KMT2AL3MBTL1LMNATSHRALDH1A1 | |
| SCHEMBL22162939 | 0.65 | KMT2A (0.54) | KMT2AMEN1HTTGFERHSD17B10 | |
| SCHEMBL697595 | 0.65 | KMT2A (0.60) | KMT2AMEN1HTTGFERHSD17B10 | |
| SCHEMBL22882716 | 0.65 | ALDH1A1 (0.57) | KMT2AMEN1HTTGFERHSD17B10 | |
| SCHEMBL6943583 | 0.64 | KMT2A (0.44) | KMT2AMEN1HTTGFERHSD17B10 | |
| SCHEMBL1927968 | 0.64 | LMNA (0.59) | KMT2AMEN1HTTGFERHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | claimed |
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | disclosed |