Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311667 | 0.82 | SIGMAR1 (0.41) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9311475 | 0.80 | BACE1 (0.42) | ALDH1A1KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL9060356 | 0.71 | GRIN2D (0.44) | SIGMAR1 | |
| SCHEMBL9059656 | 0.71 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1KMT2APOLBHTR3E | |
| SCHEMBL9059579 | 0.71 | SIGMAR1 (0.48) | SIGMAR1SLC9A1HTR3EHTR3BHTR3A | |
| SCHEMBL9059756 | 0.68 | SIGMAR1 (0.50) | SIGMAR1KMT2AMEN1 | |
| SCHEMBL9311522 | 0.68 | GRIN2D (0.46) | SIGMAR1 | |
| Methyl Alcohol SCHEMBL28859435 | 0.67 | ALDH1A1 (0.48) | ALDH1A1KMT2AHSD11B1PTGDR2SMN1; SMN2 | |
| SCHEMBL9537348 | 0.67 | MIF (0.39) | ALDH1A1KMT2ACASP3SENP7SENP6 | |
| SCHEMBL9060002 | 0.67 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536151-A1 | ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM. | BOOTS CO PLC (GB) | 1993-04-14 | — | — | EP | disclosed |