Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eniluracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD known ✓ | Q12882 | 3/20 | 0.65 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13296 | 0.84 | DPYD (0.59) | DPYDATAD2KDM4EALDH1A1GAA | |
| Eniluracil SCHEMBL37817 | 0.80 | DPYD (1.00) | DPYDATAD2ALDH1A1GAALMNA | |
| SCHEMBL189451 | 0.80 | DPYD (1.00) | DPYDATAD2KDM4EALDH1A1HPGD | |
| Thymine SCHEMBL14695416 | 0.76 | ATAD2 (0.66) | DPYDATAD2ALDH1A1GAALMNA | |
| SCHEMBL6510854 | 0.75 | DPYD (0.49) | DPYDATAD2ALDH1A1GAALMNA | |
| SCHEMBL6510851 | 0.74 | DPYD (0.47) | DPYDATAD2ALDH1A1GAALMNA | |
| Pyrimidine SCHEMBL28139051 | 0.73 | DPYD (0.46) | DPYDATAD2KDM4EALDH1A1GAA | |
| Pyridine SCHEMBL28177470 | 0.73 | DPYD (0.46) | DPYDATAD2KDM4EALDH1A1HPGD | |
| SCHEMBL28181671 | 0.70 | DPYD (0.44) | DPYDATAD2 | |
| Eniluracil SCHEMBL5392934 | 0.69 | DPYD (0.73) | DPYDATAD2ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539442-A1 | ENZYME INACTIVATORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001452-A1 | ENZYME INACTIVATORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-02-06 | — | — | WO | disclosed |