Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eniluracil SCHEMBL9539455 | 0.80 | DPYD (0.65) | DPYDALDH1A1MAPTGAAATAD2 | |
| SCHEMBL187437 | 0.78 | DPYD (0.64) | DPYDALDH1A1MCL1KDM4ENPSR1 | |
| Eniluracil SCHEMBL37817 | 0.77 | DPYD (1.00) | DPYDALDH1A1MAPTGAAATAD2 | |
| SCHEMBL5045201 | 0.75 | DPYD (0.60) | DPYDALDH1A1GAAATAD2MCL1 | |
| SCHEMBL30753833 | 0.75 | DPYD (0.59) | DPYDALDH1A1GAALMNAMCL1 | |
| SCHEMBL1051435 | 0.74 | DPYD (0.59) | DPYDALDH1A1MAPTGAAATAD2 | |
| SCHEMBL13296 | 0.74 | DPYD (0.59) | DPYDALDH1A1MAPTGAAATAD2 | |
| SCHEMBL14177211 | 0.74 | DPYD (0.59) | DPYDALDH1A1MAPTGAAATAD2 | |
| SCHEMBL28592458 | 0.72 | DPYD (0.57) | DPYDALDH1A1MAPTGAAATAD2 | |
| SCHEMBL5820610 | 0.71 | DPYD (0.55) | DPYDALDH1A1MAPTGAAATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 407 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114891041-A | Ruthenium arene complex with multiple activities and preparation method and application thereof | 重庆医科大学 | 2022-08-12 | — | — | CN | claimed |
| CN-108358854-A | A kind of preparation method of pharmaceutical intermediate 5- cyanouracils | 重庆奥舍生物化工有限公司 | 2018-08-03 | — | — | CN | claimed |
| US-20170175129-A1 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS INC (US) | 2017-06-22 | — | — | US | claimed |
| US-20170136131-A1 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | Modema Therapeutics, Inc. (US) | 2017-05-18 | — | — | US | claimed |
| EP-3157572-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | Moderna Therapeutics, Inc. (US) | 2017-04-26 | — | — | EP | claimed |
| EP-3157573-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | Moderna Therapeutics, Inc. (US) | 2017-04-26 | — | — | EP | claimed |
| US-20160304552-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC. | 2016-10-20 | — | — | US | claimed |
| EP-3080289-A2 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | Moderna Therapeutics, Inc. (US) | 2016-10-19 | — | — | EP | claimed |
| WO-2015196128-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | claimed |
| WO-2015196130-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | claimed |
| WO-2009100367-A2 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-13 | — | — | WO | claimed |
| US-20090196833-A1 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-06 | — | — | US | claimed |
| US-20080255168-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-10-16 | — | — | US | claimed |
| CN-101068549-A | Methods of administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES INC (CA) | 2007-11-07 | — | — | CN | claimed |
| EP-1827443-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | Adherex Technologies, Inc. (CA) | 2007-09-05 | — | — | EP | claimed |
| WO-2006060697-A9 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES INC (CA) | 2006-09-21 | — | — | WO | claimed |
| US-20060148753-A1 | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-07-06 | — | — | US | claimed |
| WO-2006060697-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-06-08 | — | — | WO | claimed |
| EP-0726904-A1 | 5-FLUOROURACIL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-08-21 | — | — | EP | claimed |
| WO-1995012606-A1 | 5-FLUOROURACIL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304552-A1 | MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, ADAR, NSUN3 | DPYD 250/4885ALDH1A1 1969/4885MAPT 3517/4885 |
| US-20170175129-A1 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, RNGTT, NSUN3 | DPYD 369/4885ALDH1A1 2324/4885MAPT 3589/4885 |
| US-20170136131-A1 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | NSUN2, RNGTT, NSUN3 | DPYD 369/4885ALDH1A1 2324/4885MAPT 3589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.