Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.60 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831466 | 0.80 | ALOX5 (0.70) | ALOX5SLC1A3SLC1A2SLC1A1CETP | |
| SCHEMBL8805686 | 0.76 | ALOX5 (1.00) | ALOX5SLC1A3SLC1A2SLC1A1TRPM8 | |
| SCHEMBL9541349 | 0.73 | SLC1A3 (0.50) | ALOX5SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL9542504 | 0.73 | ALOX5 (0.60) | ALOX5SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL9538808 | 0.73 | ALOX5 (0.56) | ALOX5SLC1A3SLC1A2SLC1A1CETP | |
| SCHEMBL14587482 | 0.71 | ALOX5 (0.51) | ALOX5SLC1A3SLC1A2SLC1A1CETP | |
| SCHEMBL9542445 | 0.71 | SLC1A3 (0.50) | ALOX5SLC1A3SLC1A2SLC1A1MMP2 | |
| SCHEMBL9539825 | 0.70 | ALOX5 (0.39) | ALOX5MMP2TRPM8 | |
| SCHEMBL9539738 | 0.70 | ALOX5 (0.61) | ALOX5MMP2 | |
| SCHEMBL28449128 | 0.69 | SLC1A3 (0.50) | ALOX5SLC1A3SLC1A2SLC1A1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003719-A1 | ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY | ABBOTT LABORATORIES (US) | 1993-03-04 | — | — | WO | claimed |
| WO-1993003719-A1 | ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY | ABBOTT LABORATORIES (US) | 1993-03-04 | — | — | WO | disclosed |
| US-5183818-A | Also for inhibiting leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1993-02-02 | — | — | US | disclosed |