Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.42 |
| ▸ | BCHE | P06276 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538106 | 0.85 | ACHE (0.41) | ACHEBCHEKDM4EHIF1AHSD17B10 | |
| SCHEMBL9539709 | 0.83 | ACHE (0.47) | ACHEBCHEKDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL9537204 | 0.79 | BCHE (0.45) | ACHEBCHEKDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL9536737 | 0.77 | BCHE (0.44) | ACHEBCHEKDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL9538265 | 0.76 | BCHE (0.48) | ACHEBCHEOPRM1OPRD1OPRK1 | |
| Salicylic Acid SCHEMBL9541177 | 0.76 | BCHE (0.43) | ACHEBCHEKDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL9538863 | 0.75 | KDM4E (0.42) | ACHEBCHEKDM4EALDH1A1HPGD | |
| SCHEMBL2455701 | 0.68 | ACHE (0.37) | ACHEBCHEKDM4EHIF1AHSD17B10 | |
| SCHEMBL12797973 | 0.66 | ACHE (0.60) | ACHEBCHEKDM4EALDH1A1SMN1; SMN2 | |
| Acetic Acid SCHEMBL2598855 | 0.66 | KDM4E (0.54) | ACHEBCHEKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187165-A | Eseroline derivatives; cholinergic agents; antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-02-16 | — | — | US | disclosed |