Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.39 |
| ▸ | ESRRG | P62508 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585017 | 0.88 | IKBKB (0.46) | MMP2ESRRGALOX5ESR1 | |
| SCHEMBL9584912 | 0.87 | CYP2E1 (0.45) | MMP2ALOX5CYP2C9CYP2C19 | |
| SCHEMBL9538854 | 0.83 | IKBKB (0.42) | MMP2ALOX5CYP2C9CYP2C19 | |
| SCHEMBL9539825 | 0.83 | ALOX5 (0.39) | MMP2ALOX5 | |
| SCHEMBL9585668 | 0.77 | ALOX5 (0.49) | MMP2ALOX5CYP1A2CYP2C9HPGD | |
| SCHEMBL9583758 | 0.74 | MMP2 (0.33) | MMP2ALOX5 | |
| SCHEMBL9584641 | 0.73 | MMP2 (0.37) | MMP2ALOX5 | |
| SCHEMBL9584629 | 0.72 | MMP2 (0.34) | MMP2ALOX5 | |
| SCHEMBL9584273 | 0.71 | ALOX5 (0.42) | MMP2HSD17B1HSD17B2ALOX5 | |
| SCHEMBL9375297 | 0.70 | CYP2E1 (0.50) | ALOX5CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003719-A1 | ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY | ABBOTT LABORATORIES (US) | 1993-03-04 | — | — | WO | claimed |
| US-5183818-A | Also for inhibiting leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1993-02-02 | — | — | US | disclosed |