Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585400 | 0.87 | ALDH1A1 (0.39) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL9584565 | 0.83 | NPC1 (0.41) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL9541327 | 0.81 | NPC1 (0.42) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL9584821 | 0.80 | LMNA (0.53) | NPC1RAB9ASMN1; SMN2ALOX5POLB | |
| SCHEMBL9539688 | 0.79 | SLC1A3 (0.43) | ALDH1A1TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9538817 | 0.77 | LMNA (0.48) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL9538825 | 0.76 | SLC1A3 (0.42) | ALDH1A1TSHRNPC1RAB9AHTT | |
| SCHEMBL9542445 | 0.76 | SLC1A3 (0.50) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL9585067 | 0.75 | MAPT (0.43) | ALDH1A1TSHRMAPTNPC1RAB9A | |
| SCHEMBL6122033 | 0.75 | ALDH1A1 (0.60) | ALDH1A1TSHRMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003719-A1 | ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY | ABBOTT LABORATORIES (US) | 1993-03-04 | — | — | WO | claimed |
| US-5183818-A | Also for inhibiting leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1993-02-02 | — | — | US | disclosed |