Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636224 | 0.78 | RORA (0.44) | TDP1LMNATSHRTP53ALDH1A1 | |
| SCHEMBL20274635 | 0.72 | LMNA (0.43) | TDP1ATMLMNAALDH1A1L3MBTL1 | |
| SCHEMBL6527375 | 0.71 | TP53 (0.66) | LMNATSHRTP53MAPK1GAA | |
| SCHEMBL6027390 | 0.70 | TDP1 (0.60) | TDP1SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL5553536 | 0.69 | PDE4B (0.38) | TDP1ATMSMN1; SMN2LMNATSHR | |
| SCHEMBL2731836 | 0.69 | TDP1 (0.62) | TDP1SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL11498915 | 0.68 | TSHR (0.59) | TDP1ATMSMN1; SMN2LMNATSHR | |
| SCHEMBL11053715 | 0.67 | ALDH1A1 (0.53) | LMNATP53ALDH1A1MAPTPOLB | |
| SCHEMBL4925728 | 0.67 | KMT2A (0.46) | TDP1SMN1; SMN2LMNATP53ALDH1A1 | |
| SCHEMBL6279426 | 0.67 | HCAR2 (0.39) | LMNATP53ALDH1A1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530994-A1 | Quinazoline derivatives as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1993004047-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-04 | — | — | WO | disclosed |