Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539618 | 0.89 | PDE10A (0.46) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL9538681 | 0.88 | PDE10A (0.45) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333779 | 0.87 | PDE10A (0.48) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333523 | 0.82 | PDE10A (0.43) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333478 | 0.82 | PDE10A (0.48) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333408 | 0.80 | PDE10A (0.40) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333269 | 0.80 | PDE10A (0.44) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL6474693 | 0.78 | PDE10A (0.43) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL9568947 | 0.77 | CCR1 (0.49) | NOS3NOS1NOS2ALDH1A1CCR1 | |
| SCHEMBL10333166 | 0.77 | PDE10A (0.40) | PDE10ANOS3NOS1NOS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993002077-A1 | BENZIMIDAZOLES | FISONS PLC (GB) | 1993-02-04 | — | — | WO | claimed |
| EP-0526033-A1 | Benzimidazoles | FISONS plc (GB) | 1993-02-03 | — | — | EP | claimed |
| EP-0526033-A1 | Benzimidazoles | FISONS plc (GB) | 1993-02-03 | — | — | EP | disclosed |