Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538681 | 0.89 | PDE10A (0.45) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL9540847 | 0.89 | PDE10A (0.45) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333779 | 0.85 | PDE10A (0.48) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL14141049 | 0.84 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2ALDH1A1CBFB | |
| SCHEMBL10333478 | 0.82 | PDE10A (0.48) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL6474693 | 0.79 | PDE10A (0.43) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333523 | 0.79 | PDE10A (0.43) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333269 | 0.78 | PDE10A (0.44) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333166 | 0.78 | PDE10A (0.40) | PDE10ANOS3NOS1NOS2NPC1 | |
| SCHEMBL10333411 | 0.78 | PDE10A (0.42) | PDE10ANOS3NOS1NOS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993002077-A1 | BENZIMIDAZOLES | FISONS PLC (GB) | 1993-02-04 | — | — | WO | claimed |
| EP-0526033-A1 | Benzimidazoles | FISONS plc (GB) | 1993-02-03 | — | — | EP | claimed |
| US-20170165248-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2017-06-15 | — | — | US | disclosed |
| US-20170165248-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2017-06-15 | — | — | US | disclosed |
| US-20150079186-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2015-03-19 | — | — | US | disclosed |
| US-20150079186-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2015-03-19 | — | — | US | disclosed |
| US-8962688-B2 | Method for the treatment of gastrointestinal disorders | SUCAMPO AG (CH) | 2015-02-24 | — | — | US | disclosed |
| US-8962688-B2 | Method for the treatment of gastrointestinal disorders | SUCAMPO AG (CH) | 2015-02-24 | — | — | US | disclosed |
| US-20130273168-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2013-10-17 | — | — | US | disclosed |
| US-20130273168-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2013-10-17 | — | — | US | disclosed |
| US-8114435-B2 | Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a NSAID | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |
| US-20080003281-A1 | Modified Release Tablet Formulations for Proton Pump Inhibitors | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | US | disclosed |
| US-20070276006-A1 | Method for the treatment of gastrointestinal disorders | SUCAMPO AG | 2007-11-29 | — | — | US | disclosed |
| US-20070276006-A1 | Method for the treatment of gastrointestinal disorders | SUCAMPO AG | 2007-11-29 | — | — | US | disclosed |
| US-20070276007-A1 | Administration of pharmaceuticals | CEDERBERG CHRISTER | 2007-11-29 | — | — | US | disclosed |
| US-20070276007-A1 | Administration of pharmaceuticals | CEDERBERG CHRISTER | 2007-11-29 | — | — | US | disclosed |
| US-20070053981-A1 | Solid composition comprising a proton pump inhibitor | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | US | disclosed |
| US-20070053981-A1 | Solid composition comprising a proton pump inhibitor | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | US | disclosed |
| WO-1993002077-A1 | BENZIMIDAZOLES | FISONS PLC (GB) | 1993-02-04 | — | — | WO | disclosed |
| EP-0526033-A1 | Benzimidazoles | FISONS plc (GB) | 1993-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150079186-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | PGA5, PGC, SI | PDE10A 741/4885NOS3 1428/4885NOS1 2806/4885 |
| US-20170165248-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | PGA5, PGC, SI | PDE10A 741/4885NOS3 1428/4885NOS1 2806/4885 |
| US-20130273168-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | PGA5, PGC, SI | PDE10A 741/4885NOS3 1428/4885NOS1 2806/4885 |
| US-20080003281-A1 | Modified Release Tablet Formulations for Proton Pump Inhibitors | SI, PPIA, PPID | PDE10A 372/4885NOS3 2818/4885NOS1 1540/4885 |
| US-20070276006-A1 | Method for the treatment of gastrointestinal disorders | SLC10A2, PGA5, PTGS2 | PDE10A 945/4885NOS3 2211/4885NOS1 2440/4885 |
| US-20070053981-A1 | Solid composition comprising a proton pump inhibitor | PGA5, ATP6AP1, MLN | PDE10A 1973/4885NOS3 4714/4885NOS1 4551/4885 |
| US-20070276007-A1 | Administration of pharmaceuticals | ATP4A, ATP1A2, ATP1A4 | PDE10A 1993/4885NOS3 4578/4885NOS1 4174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.