Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SDCBP | O00560 | 1/20 | 0.34 |
| ▸ | SDC2 | P34741 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604537 | 0.88 | SORT1 (0.46) | MAOAL3MBTL1SORT1BCHECES1 | |
| SCHEMBL5214053 | 0.85 | HTR2A (0.44) | MAOASORT1BCHECES1TDO2 | |
| SCHEMBL5222708 | 0.82 | MEN1 (0.51) | TP53TDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL6602287 | 0.76 | NR1H3 (0.39) | MAOARNASEH1MEN1KMT2ATYR | |
| SCHEMBL6046310 | 0.74 | MAOA (0.44) | MAOABCHECES1RNASEH1MEN1 | |
| SCHEMBL7264066 | 0.74 | MAOA (0.44) | MAOABCHECES1RNASEH1MEN1 | |
| SCHEMBL4774575 | 0.74 | MAOA (0.40) | MAOATP53TDP1L3MBTL1BCHE | |
| SCHEMBL6603867 | 0.74 | MAPT (0.47) | MAOAL3MBTL1BCHECES1MEN1 | |
| SCHEMBL6600290 | 0.73 | ALPL (0.47) | L3MBTL1CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL1818127 | 0.72 | MAOA (0.48) | MAOATP53TDP1L3MBTL1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014086-A1 | SUBSTITUTED 1-ISOQUINOLONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-07-22 | — | — | WO | disclosed |