Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.32 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MGMT | P16455 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542967 | 0.89 | CSNK2A2 (0.34) | MEN1CSNK2A2RAB9ACSNK2BCSNK2A1 | |
| SCHEMBL9539346 | 0.88 | MEN1 (0.32) | MEN1CSNK2A2RAB9ACSNK2BCSNK2A1 | |
| SCHEMBL9540355 | 0.87 | KDM4E (0.32) | KDM4ETP53 | |
| SCHEMBL9540494 | 0.85 | KDM4E (0.38) | RAB9AKMT2APDPK1KDM4ETP53 | |
| SCHEMBL9543012 | 0.80 | LMNA (0.43) | RAB9AKDM4E | |
| SCHEMBL9539357 | 0.76 | KDM4E (0.34) | KDM4E | |
| SCHEMBL9542969 | 0.73 | KDM4E (0.40) | RAB9AKMT2APDPK1KDM4ETP53 | |
| SCHEMBL9540477 | 0.73 | KDM4E (0.38) | MEN1RAB9AKMT2APDPK1KDM4E | |
| SCHEMBL9542989 | 0.73 | ELANE (0.34) | — | |
| SCHEMBL9540192 | 0.72 | CDK1 (0.38) | RAB9AKDM4ETP53MGMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | claimed |