Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MGMT | P16455 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542969 | 0.90 | KDM4E (0.40) | KDM4ETP53HSD17B10HPGDRAB9A | |
| SCHEMBL9540477 | 0.89 | KDM4E (0.38) | KDM4ETP53HSD17B10HPGDRAB9A | |
| SCHEMBL9543012 | 0.87 | LMNA (0.43) | KDM4EHPGDRAB9ATSHRSMN1; SMN2 | |
| SCHEMBL9541784 | 0.85 | MEN1 (0.32) | KDM4ETP53RAB9AKMT2AMGMT | |
| SCHEMBL9540355 | 0.81 | KDM4E (0.32) | KDM4ETP53HPGDALDH1A1 | |
| SCHEMBL9540456 | 0.79 | ALOX5 (0.36) | KDM4ETP53HSD17B10HPGDRAB9A | |
| SCHEMBL9540186 | 0.77 | LMNA (0.46) | KDM4EHPGDRAB9ATSHRMAPT | |
| SCHEMBL9540433 | 0.77 | LMNA (0.43) | KDM4EHPGDRAB9ATSHRMAPT | |
| SCHEMBL9540446 | 0.75 | ALDH1A1 (0.36) | HSD17B10HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL370253 | 0.75 | KDM4E (0.45) | KDM4ETP53HSD17B10HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | claimed |
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | disclosed |