Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540186 | 0.91 | LMNA (0.46) | LMNASMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9540433 | 0.90 | LMNA (0.43) | LMNASMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9540456 | 0.82 | ALOX5 (0.36) | LMNASMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9542969 | 0.78 | KDM4E (0.40) | LMNASMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9540446 | 0.72 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1HPGDCDK1CCNB1 | |
| SCHEMBL9542967 | 0.70 | CSNK2A2 (0.34) | SMN1; SMN2KDM4ERAB9ATSHR | |
| SCHEMBL9540192 | 0.68 | CDK1 (0.38) | SMN1; SMN2KDM4EHPGDRAB9ACDK1 | |
| SCHEMBL9542989 | 0.67 | ELANE (0.34) | ELANEL3MBTL1 | |
| SCHEMBL7374428 | 0.65 | LMNA (0.44) | LMNASMN1; SMN2NPC1ALDH1A1XDH | |
| SCHEMBL7368064 | 0.65 | LMNA (0.44) | LMNACYP1A2CYP2D6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | claimed |