Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805920 | 0.83 | KDM4E (0.58) | NPC1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL15548524 | 0.82 | ALOX15 (0.57) | TP53NPC1KMT2AMAPTALDH1A1 | |
| SCHEMBL220681 | 0.82 | NPC1 (0.64) | TP53NPC1KMT2AMAPTALDH1A1 | |
| SCHEMBL20204164 | 0.81 | TP53 (0.48) | TP53NPC1KMT2AMAPTALDH1A1 | |
| SCHEMBL9543811 | 0.79 | HDAC3 (0.44) | TP53NPC1KMT2AMAPTALDH1A1 | |
| SCHEMBL11184716 | 0.78 | TAS1R3 (0.46) | KMT2AMAPTALDH1A1MEN1ELANE | |
| SCHEMBL27580216 | 0.76 | KDM4E (0.58) | NPC1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL11252289 | 0.76 | KDM4E (0.55) | TP53NPC1MAPTHPGDRAB9A | |
| SCHEMBL1914036 | 0.76 | KDM4E (0.46) | KMT2AMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL14744132 | 0.76 | KDM4E (0.72) | TP53NPC1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014086-A1 | SUBSTITUTED 1-ISOQUINOLONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-07-22 | — | — | WO | disclosed |