Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9543422 | 0.80 | DHFR (0.43) | DHFRNPC1TP53GLAMAPK1 | |
| SCHEMBL9541716 | 0.80 | DHFR (0.43) | DHFRNPC1TP53GLAMAPK1 | |
| SCHEMBL9540646 | 0.75 | DHFR (0.45) | DHFR | |
| SCHEMBL9544509 | 0.74 | DHFR (0.50) | DHFR | |
| SCHEMBL9544514 | 0.74 | DHFR (0.48) | DHFR | |
| SCHEMBL10689192 | 0.70 | DHFR (0.50) | DHFR | |
| SCHEMBL27188510 | 0.65 | DHFR (0.52) | DHFR | |
| SCHEMBL18704258 | 0.65 | CA1 (0.53) | NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL9541999 | 0.64 | DHFR (0.66) | DHFR | |
| SCHEMBL9542041 | 0.63 | DHFR (0.52) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013102-A1 | DEAZAAMINOPTERINS | SOUTHERN RESEARCH INSTITUTE (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5077404-A | Cyclized 5,10-dideazaaminopterin compounds | SRI INTERNATIONAL | 1991-12-31 | — | — | US | disclosed |